i.Mune™ PID* is a quantitative test to determine the percentages and absolute** counts of human CD3+, CD4+, CD8+ T-, B-, NK cells, TSDR+ regulatory T cells, neutrophils and monocytes in peripheral whole blood or in blood dried on filter paper.
Allows molecular quantification of:
- Overall T cells (CD3+)
- Helper T cells (CD4+)
- Cytotoxic T cells (CD8+)
- B cells (CD 19+)
- NK cells (CD16+ CD56dim)
- TSDR+ regulatory T cells (Treg)
Can be useful for**:
- Early detection of immune cell dysregulation in patients with symptoms of primary immunodeficiency and immune regulatory disorders
- Monitoring of patients with primary and secondary immunodeficiency and immune regulatory disorders under therapy
*i.Mune™ PID is for research use, only and has not been registered as an IVD product and has not been approved or cleared by a regulatory authority.
**The above clinical applications have been established using technologies currently being employed in clinical laboratory routine (e.g. flow cytometry). Epimune has demonstrated equivalence of its epigenetic immune cell quantification method to flow cytometry (in whole blood) and the concordance of epigenetic immune cell quantification between whole blood and dried blood spots (Baron et al., Science Transl Med, 2018)