Cardiovascular and Renal Systems

α1-Microglobulin (α1-M), ELISA Article number: K 6710 Tests: 96 Tests Incubation time: 1h; 1h; 15min Volume: 10 µl Matrix: Plasma, Serum, Urine Standards: 0.019-1.5 mg/l Method: ELISA Details (PDF) Kit Manual To access these files, you need the Acrobat Reader Alpha 1 Microglobulin, a glycoprotein heterogeneous in charge, was reported to occur both as a monomer with 31kDa but also as a polymer with 90 kDa in a covalent binding with one of the two alpha chains of the monomeric Immunoglobulin A. Alpha-1-Mikroglobulin is produced in the liver and is a protein with a small molecular weight. These proteins are metabolised in the kidneys and in a healthy person, only minor amounts can be detected in urine. If the glomerular filtration rate is limited, then the increase of Alpha-1-Microglobulin is seen in serum. If the relationship between the total sum of Albumin-IgG, Alpha-1-Microglobulin in comparison to the total protein in urine is disturbed, then this indicates a prerenal protinuria.