The intended use of the Card Processing Automation 200™ (CPA200™) is to fill a 96-wells PCR plate with human’s saliva or blood samples extracted from COPAN NUCLEIC-CARD™ or other compatible sample collection devices. Extraction is performed trough a cylindrical punch head (puncher), which detaches a paper disk from the card containing the DNA sample and places it into one well of the PCR plate underneath. CPA200™ is a semi-automatic instrument: the user manually loads a card, chooses the position where to extract the DNA sample through a laser pointer and launches the punching operation, which is automatically performed by the system. CPA200™ is compatible with all the sample collection devices currently present in the market, including COPAN NUCLEIC-CARD™, Whatman FTA™ cards, Bode Buccal DNA Collector™ and Bode Buccal 2™. Performances are optimized when processing Copan framed NUCLEIC-CARD™ with cleaning area: the user has the possibility to load a card on the integrated card holder, which automatically handles the card when punching and performs the cleaning strike to prevent any DNA carry-over effect. A 96-wells PCR plate can contain up to 96 different Human DNA samples: for this reason, CPA200™ equips barcode readers to ensure the traceability of processed samples and a vision system in order to check the presence of disks inside plate wells.