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The storage of whole blood or red corpuscles is associated with the formation of considerable quantities of microaggregates between 25 μm and 40μm.
These microaggregates are fundamentally made up of degenerated leukocytes and thrombocytes, fragments of red blood cells and other cells, lipids, lipoproteins and precipitated denaturated albumin.
The conditions and the storage period influence the type and amount of microaggregates present.
The scientific literature shows that microaggregates with larger dimensions (i.e. more than 40μm) are often present in extremely high concentrations.
It has also been shown that a relation exists between acute respiratory failure and the presence of microaggregates in the pulmonary circulation of patients who have undergone massive transfusions.
Therefore it is necessary to filter the blood used for transfusions. This allows the larger microaggregates to be removed which protects the pulmonary microcirculation. Transafe ®  is the ideal filter for transfusion safety.