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Tetanus antitoxin is given prophylactically to persons at the risk of tetanus infection by infected wounds or severe wounds. A dose of 1500 IU should be given intramuscularly or subcutaneously and the dose may doubled or trebled in case multiple and severe wounds. Prophylactic dose is also given in surgical operations as post operative care.
Along with this passive immunization it is advisable to initiate active immunization with adsorbed Tetanus toxoid.