NEUROLITH for TPS

Transcranial Pulse Stimulation (TPS) for the stimulation of brain regions in patients with Alzheimer's disease

The key mechanism induced by TPS is mechanotransduction. The stimulation of growth factors, primarily VEGFnot only improves cerebral blood flow, but also promotes the formation of new blood vessels (angiogenesis) and nerve regeneration. An additional effect is the release of nitric oxide (NO), which leads to direct vasodilation and improved blood circulation.

Biological effects of TPS

• Mechanotransduction
• Increase in cell permeability
• Stimulation of mechanosensitive ion channels
• Release of nitric oxide (NO), which leads to vasodilation, increased metabolic activity and angiogenesis and has an anti-inflammatory effect
• Stimulation of vascular growth factors (VEGF)
• Stimulation of BDNF
• Migration and differentiation of stem cells

TPS can stimulate deep cerebral regions, reaching as much as 8 cm into the brain. Owing to the short duration of the TPS stimulation, tissue heating is avoided. The pulses applied to the treatment area thus develop their maximum clinical effectiveness. TPS treatment is performed through the closed skull. The patient is not immobilized during the treatment and able to move freely. TPS treatment has been shown to significantly improve CERAD test performance and to reduce Beck’s depression index in patients with mild to moderate dementia. Over 1500 treatments have already been performed using the NEUROLITH system.

Advantages of TPS

• 6 treatment sessions in 2 weeks
• Outpatient treatment (30 minutes/session)
• Painless and without side effects
• Personalized treatment based on MRI data
• Adjuvant cognitive training not required
• Shaving of the scalp not required
• No immobilization of the patient during treatment