Methylation Seq... DNA methylation is one of the major patterns of epigenetic modification, which is widely involved in the expression and regulation of genes and genomes. DNA methylation generally existing in the bio-circle is needed by the plants and mammals for normal growth and development. For the plants, DNA methylation plays a critical role in the process of gene expression and cellular differentiation. It mainly researches the regulation of gene expression during plant development and prevention of external sequence insertion, so as to maintain the stability of the plant genome. For mammals, DNA methylation usually occurs on CpG dinucleotide. It mainly researches the gene regulation and the key biomarker for methylation that may cause diseases.