Human Genome Sequencing

Human Genome Sequencing 選擇其他單元： Human Genome Se... Introduction The Human Genome Project (HGP) conducts human genome mapping by decoding the human genomic sequence, which opens the doors for human genome research successfully. NGS technology can research the human genome more comprehensively. Starting from the perspective of various omics, NGS technologies can fully show the changes of various omics objectively. Under the whole genome scale, the Whole Human Genome Re-Sequencing technology combines Short-Reads, Paired-Ends and Insert-Size of different sizes for sequencing. It can find the specific variations for the coding area and non-coding area such as Single Nucleotide Polymorphisms (SNPs, Insertions and Deletions (InDels), Structure Variations (SVs) and Copy Number Variations (CNVs), and sequence the regulation mechanism at the epigenetic level including DNA methylation. With the whole genome re-sequencing and bioinformatics analysis, it deeply explores the human genome and its functions. Therefore, countries from around the world successively launched the large human genome projects (such as: The 1000 Genomes Project, Netherlands, Japan; Singapore). By sequencing thousands of whole human genomes for different countries, it was able to build the human gene database, with the aim of providing the information of inherited variation for human genomes, which can be applied in disease detection, prevention and personalized medicine. Whole Human Genome Re-Sequencing techn