Human BRCA1/2 Gene Mutations Detection Kit
Human BRCA1/2 Gene Mutations Detection Kit Human BRCA1/2 Gene Mutations Detection Kit Next Genetation Sequencing CE-IVD Certificate No. MDD-SZ-XW-160321 Only for research use in China BRCA 1/2 Gene Mutation and Breast Cancer, Ovarian Cancer About 2% of women with breast cancer and 10% -15% of women with ovarian cancer carry BRCA1 or BRCA2 gene mutations. BRCA1 and BRCA2 mutations are closely related to the occurrence of familial breast cancer. According to the Breast Cancer Information Core (BIC), there are more than 3,000 kinds of BRCA1 and BRCA2 gene mutations, which are distributed throughout the whole coding region. The most common types of pathogenic mutations are frameshift mutations, nonsense mutations, while there are no obvious mutation hotspots. Most mutations lead to the formation of truncated proteins, resulting in the loss of BRCA1 or BRCA2 protein function and leading to the occurrence of tumor.