EAST Enzym Allergo Sorbent Test for the quantitative determination of allergen-specific IgE in human serum or plasma with allergen coated discs. BACKROUND The worldwide frequency of allergies has increased significantly over the past decades. The term allergy is often used for Type I hypersensitivity reactions (immediate type reactions), whose symptoms generally occur within 30-60 minutes after contact with the allergen. The most frequent symptoms are: hay fever (rhinitis), conjunctivitis, hives (urticaria), allergic asthma and as the most dangerous manifestation anaphylaxis (the anaphylactic shock). The allergens causing Type I hypersensitivity reactions are mostly proteins derived from the natural environment e.g. plant pollen, animal hair, food, mites, and insect venoms. The characteristics of Type I allergies is the involvement of allergen specific immunoglobulins (antibodies) of class E (sIgE). Hence, the detection of sIgE is an important tool of modern allergy diagnostics. The specific IgE EAST contributes to the diagnosis of Typ I allergies. It is available with 4 or 6 calibrators.